EGF and TGF-<b/>1 Effects on Thyroid Function

doi:10.4061/2011/431718

Article

EGF and TGF-<b/>1 Effects on Thyroid Function

1 Jan 2011

Abstract excerpt

Normal epithelial thyroid cells in culture are inhibited by TGF-β1. Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory effect. Loss of TGF-β responsiveness could be due to a reduced expression of TGF-β receptors, as shown in transformed rat thyroid cell lines and in human thyroid tumors, or to alterations of other genes controlling TGF-β signal transduction pathway. However,...

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