Article
Genetics of hereditary colon cancer.
Annual review of genetics - 1 Jan 1995
de la Chapelle A, Peltomäki P
Abstract excerpt
A new mechanism leading to cancer has been delineated in the last two years when genes whose mutations cause susceptibility to hereditary nonpolyposis colorectal cancer, HNPCC, have been mapped, cloned, and characterized. The genes involved belong to a family of DNA mismatch repair genes, and the homozygous effects of their mutations lead to a so-called mutator or replication error phenotype characterized by...
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