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Article

Identification of common and distinct residues involved in the interaction of alphai2 and alphas with adenylyl cyclase.

The Journal of biological chemistry - 15 Aug 1997

Grishina G, Berlot C H

Abstract excerpt

The G protein alpha subunits, alphas and alphai2, have stimulatory and inhibitory effects, respectively, on a common effector protein, adenylyl cyclase. These effects require a GTP-dependent conformational change that involves three alpha subunit regions (Switches I-III). alphas residues in three adjacent loops, including Switch II, specify activation of adenylyl cyclase. The adenylyl cyclase-specifying region of...

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Identifiers

PMID: 9252377
DOI: 10.1074/jbc.272.33.20619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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