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Article

Universal allosteric mechanism for Gα activation by GPCRs.

Nature - 13 Aug 2015

Flock Tilman, Ravarani Charles N J, Sun Dawei, Venkatakrishnan A J, Kayikci Melis, Tate Christopher G, Veprintsev Dmitry B, Babu M Madan

Abstract excerpt

G protein-coupled receptors (GPCRs) allosterically activate heterotrimeric G proteins and trigger GDP release. Given that there are ∼800 human GPCRs and 16 different Gα genes, this raises the question of whether a universal allosteric mechanism governs Gα activation. Here we show that different GPCRs interact with and activate Gα proteins through a highly conserved mechanism. Comparison of Gα with the small G...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits

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Share to Protein Structure, Secondary

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Share to Receptors, G-Protein-Coupled

Source

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Identifiers

PMID: 26147082
DOI: 10.1038/nature14663
PMCID: PMC4866443

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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