Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis.

The Journal of clinical investigation - 1 Aug 1997

Bertoni R, Sidney J, Fowler P, Chesnut R W, Chisari F V, Sette A

Abstract excerpt

The present study was designed to determine if highly conserved hepatitis B virus (HBV)-derived peptides that bind multiple HLA class I alleles with high affinity are recognized as cytotoxic T lymphocyte (CTL) epitopes in acutely infected patients. Peripheral blood mononuclear cells from 67 patie...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Hepatitis B virus
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA Antigens

Share to Peptides

Share to Prognosis

Share to T-Lymphocytes

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9239396
DOI: 10.1172/JCI119559
PMCID: PMC508216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9239396-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis.PMID 9239396Read ↗

Immunization with the HBV core 18-27 epitope elicits CTL responses in humans expressing different HLA-A2 supertype molecules.Semantic proximity Read ↗

Identification of HLA-A3 and -B7-restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C.Semantic proximity Read ↗

Majority of peptides binding HLA-A*0201 with high affinity crossreact with other A2-supertype molecules.Semantic proximity Read ↗

Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: biological validation of the proposed HLA A24 supertype.Semantic proximity Read ↗

HLAsupE: an integrated database of HLA supertype-specific epitopes to aid in the development of vaccines with broad coverage of the human population.Semantic proximity Read ↗

A framework to sub-type HLA supertypes.Semantic proximity Read ↗

Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism.Semantic proximity Read ↗

Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles.Semantic proximity Read ↗

Extensive HLA class I allele promiscuity among viral CTL epitopes.Semantic proximity Read ↗

Cross-allele cytotoxic T lymphocyte responses against 2009 pandemic H1N1 influenza A virus among HLA-A24 and HLA-A3 supertype-positive individuals.Semantic proximity Read ↗

Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes.Semantic proximity Read ↗

HLA class I supertypes: a revised and updated classification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.