Article
Simultaneous prediction of binding capacity for multiple molecules of the HLA B44 supertype.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2003
Sidney John, Southwood Scott, Pasquetto Valerie, Sette Alessandro
Abstract excerpt
We selected for study a set of B44-supertype molecules collectively represented in >40% of the individuals in all major ethnicities (B*1801, B*4001, B*4002, B*4402, B*4403, and B*4501). The peptide-binding specificity of each molecule was characterized using single amino acid substitution analogues and nonredundant peptide libraries. In all cases, only peptide ligands with glutamic acid in position 2 were...
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