Article
Extension of the Haseman-Elston method to multiple alleles and multiple loci: theory and practice for candidate genes.
Annals of human genetics - 1 May 1997
Stoesz M R, Cohen J C, Mooser V, Marcovina S, Guerra R
Abstract excerpt
The Haseman & Elston (1972) sibling-pair regression method has been used to detect and estimate the variance contribution to observed values of a quantitative trait by allelic variation in specific candidate genes. The procedure was developed under a model with a single biallelic trait locus. Thi...
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