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Article

Extension of the Haseman-Elston method to multiple alleles and multiple loci: theory and practice for candidate genes.

Annals of human genetics - 1 May 1997

Stoesz M R, Cohen J C, Mooser V, Marcovina S, Guerra R

Abstract excerpt

The Haseman & Elston (1972) sibling-pair regression method has been used to detect and estimate the variance contribution to observed values of a quantitative trait by allelic variation in specific candidate genes. The procedure was developed under a model with a single biallelic trait locus. This assumption does not hold for several known systems. In this paper we prove that for candidate gene analysis the...

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PMID: 9250355
DOI: 10.1046/j.1469-1809.1997.6130263.x

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