Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A comparison of univariate and multivariate tests for genetic linkage.

Genetic epidemiology - 1 Jan 1993

Amos C I, Laing A E

Abstract excerpt

A variety of robust and model-dependent genetic linkage methods were applied to log transformed lipid levels from a large pedigree in which the LDL receptor defect has been shown to segregate by molecular biologic techniques. Application of the Haseman-Elston and a variance-components based test for linkage identified LDL and cholesterol as cosegregating with the marker C3, which is genetically linked to the LDL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Aberrations
Share to Chromosome Disorders
Share to Genetic Linkage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Likelihood Functions

Share to Lipids

Share to Models, Genetic

Share to Multivariate Analysis

Source

Identifiers

PMID: 8314079
DOI: 10.1002/gepi.1370100657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A comparison of univariate and multivariate tests for genetic linkage.PMID 8314079Read ↗

A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype.Semantic proximity Read ↗

Empirical evaluation of genome scans for linkage of a quantitative trait associated with a complex disorder.Semantic proximity Read ↗

Gamma regression improves Haseman-Elston and variance components linkage analysis for sib-pairs.Semantic proximity Read ↗

Linkage analysis: principles and methods for the analysis of human quantitative traits.Semantic proximity Read ↗

Quantitative trait linkage analysis by generalized estimating equations: unification of variance components and Haseman-Elston regression.Semantic proximity Read ↗

A fast linkage method for population GWAS cohorts with related individuals.Semantic proximity Read ↗

A statistically robust variance-components approach for quantitative trait linkage analysis.Semantic proximity Read ↗

Design and analysis of genetic association studies to finely map a locus identified by linkage analysis: assessment of the extent to which an association can account for the linkage.Semantic proximity Read ↗

Extension of the Haseman-Elston method to multiple alleles and multiple loci: theory and practice for candidate genes.Semantic proximity Read ↗

Testing for linkage under robust genetic models.Semantic proximity Read ↗

Variance component methods for detecting complex trait loci.Semantic proximity Read ↗

Logarithm of odds (lods) for linkage in complex inheritance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.