Article
Haseman and Elston revisited.
Genetic epidemiology - 1 Jul 2000
Elston R C, Buxbaum S, Jacobs K B, Olson J M
Abstract excerpt
Haseman and Elston (H-E) [1972] proposed a method to detect quantitative trait loci by linkage to a marker. The squared sib-pair trait difference is regressed on the proportion of marker alleles the pair is estimated to share identical by descent: a significantly negative regression coefficient suggests linkage. It has been shown that a maximum likelihood method that directly models the sib-pair covariance has...
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