Haseman and Elston revisited.

doi:10.1002/1098-2272(200007)19:1<1::AID-GEPI1>3.0.CO;2-E

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Article

Haseman and Elston revisited.

Genetic epidemiology - 1 Jul 2000

Elston R C, Buxbaum S, Jacobs K B, Olson J M

Abstract excerpt

Haseman and Elston (H-E) [1972] proposed a method to detect quantitative trait loci by linkage to a marker. The squared sib-pair trait difference is regressed on the proportion of marker alleles the pair is estimated to share identical by descent: a significantly negative regression coefficient s...

Topics

Alleles
Computer Simulation
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Genetic Variation
Humans
Linear Models
Models, Statistical
Nuclear Family
Polymorphism, Genetic

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