Article
A bivariate Haseman-Elston method and application to the analysis of asthma-related phenotypes on chromosome 5q.
Genetic epidemiology - 1 Jan 2001
Ziegler A, Böddeker I R, Geller F
Abstract excerpt
We propose a bivariate combination of different Haseman-Elston (HE) methods for model free linkage analysis of quantitative traits. Adjustments for correlations of phenotypes and sibship sizes > 2 are performed using generalized estimating equations (GEE). All calculations are carried out with freely available software packages. We illustrate the application of standard HE methods, the unified HE method, and our...
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