Article
Matrix representation of the Haseman-Elston method.
Theoretical population biology - 1 Apr 1999
Drigalenko E
Abstract excerpt
The Hasemann-Elston method of linkage detection is based on the probabilities of a sib pair having 0, 1, or 2 alleles identical by descent (IBD) at a marker and a trait locus. These probabilities form a 3x3 matrix. Here, the characteristic values and characteristic vectors of this matrix were used to clarify the structure of the equations and to simplify calculations. As examples, the regression coefficients were...
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