An efficient method to handle the 'large p, small n' problem for genomewide association studies using Haseman-Elston regression.

Abstract excerpt

The 'large p, small n' problem in genomewide association studies (GWAS) is an important subject in genetic studies. Many approaches have been proposed for this issue, but none of them successfully combine the Haseman-Elston (H-E) regression with sliding-window scan approaches in GWAS. In this article, we extended H-E regression to GWAS, and replaced original data with different measurements of phenotype of sib...

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