Stem cell kinetics and intestinal cancer.

Abstract excerpt

The conventional view that intestinal stem cells divide every few days so that each stem cell undergoes several thousand divisions in a lifetime is challenged. It is proposed that fully differentiated cells, even in old age, are no more than sixty divisions from the zygote. This concept leads to a model in which the intestinal crypts are maintained by a linear hierarchy of stem cells. The model is consistent with...

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