The crypt cycle and the asymptotic dynamics of the proportion of differently sized mutant crypt clones in the mouse intestine.

Abstract excerpt

The dynamics of clones of intestinal epithelial crypts populated by mutant stem cells offers the hope of new and independent evidence of continued crypt replication throughout adult life, an important prediction of recent models of intestinal stem cell biology. It is shown here that the experimentally most tractable measurement--scoring of the fraction of groups of mutant crypts found as isolated singletons,...

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