Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutation, monoclonality and stochastic models of stem cell organization in the intestinal crypt.

Journal of theoretical biology - 21 Feb 1993

Loeffler M, Birke A, Winton D, Potten C

Abstract excerpt

Among highly proliferating tissues the intestinal tissue is of particular interest. Techniques are available that permit an insight into how intestinal crypts as the basic macroscopic tissue unit are regenerated from a small population of self-maintaining stem cells. However, neither the precise number of these stem cells nor their properties are known. We have recently suggested a model of stem cell organization...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Epithelial Cells
Share to Intestinal Mucosa

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Biological

Share to Mutation

Share to Stem Cells

Share to Stochastic Processes

Source

Identifiers

PMID: 8501919
DOI: 10.1006/jtbi.1993.1031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutation, monoclonality and stochastic models of stem cell organization in the intestinal crypt.PMID 8501919Read ↗

Modeling of stem cell dynamics in human colonic crypts in silico.Semantic proximity Read ↗

A Comprehensive Model of the Spatio-Temporal Stem Cell and Tissue Organisation in the Intestinal CryptSemantic proximity Read ↗

The Implications of Small Stem Cell Niche Sizes and the Distribution of Fitness Effects of New Mutations in Aging and TumorigenesisSemantic proximity Read ↗

The crypt cycle and the asymptotic dynamics of the proportion of differently sized mutant crypt clones in the mouse intestine.Semantic proximity Read ↗

Stochastic model for cell population dynamics quantifies homeostasis in colonic crypts and its disruption in early tumorigenesisSemantic proximity Read ↗

A stem cell niche theory of intestinal crypt maintenance based on a study of somatic mutation in colonic mucosa.Semantic proximity Read ↗

Stochastic model for cell population dynamics quantifies homeostasis in colonic crypts and its disruption in early tumorigenesis.Semantic proximity Read ↗

Colon Stem Cell and Crypt Dynamics Exposed by Cell Lineage ReconstructionSemantic proximity Read ↗

Stem cell kinetics and intestinal cancer.Semantic proximity Read ↗

Intestinal crypt properties fit a model that incorporates replicative ageing and deep and proximate stem cells.Semantic proximity Read ↗

Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation.Semantic proximity Read ↗

An integrative computational model for intestinal tissue renewalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.