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Article

Influence of different proton pump inhibitors on activity of cytochrome P450 assessed by [(13)C]-aminopyrine breath test.

Journal of clinical pharmacology - 1 Mar 2012

Kodaira Chise, Uchida Shinya, Yamade Mihoko, Nishino Masafumi, Ikuma Mutsuhiro, Namiki Noriyuki, Sugimoto Mitsushige, Watanabe Hiroshi, Hishida Akira, Furuta Takahisa

Abstract excerpt

Aminopyrine is metabolized by cytochrome P450 (CYP) in the liver. The investigators evaluated influences of different PPIs on CYP activity as assessed by the [(13)C]-aminopyrine breath test ([(13)C]-ABT). Subjects were 15 healthy volunteers with different CYP2C19 status (5 rapid metabolizers [RMs], 5 intermediate metabolizers [IMs], and 5 poor metabolizers [PMs]). Breath samples were collected before and every 15...

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PMID: 21415279
DOI: 10.1177/0091270010397728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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