Article
Chlorpheniramine plasma concentration and histamine H1-receptor occupancy.
Clinical pharmacology and therapeutics - 1 Aug 1995
Yasuda S U, Wellstein A, Likhari P, Barbey J T, Woosley R L
Abstract excerpt
The plasma concentration-response relationship of the antihistamine chlorpheniramine is poorly characterized. This study examined concurrently the concentrations of chlorpheniramine and presence of H1-receptor antagonist in plasma after administration of 8 mg chlorpheniramine in normal volunteers. Six extensive metabolizers and five poor metabolizers, as judged by CYP2D6 phenotype (dextromethorphan metabolic...
Topics
- Adult
- Animals
- Chlorpheniramine
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Dose-Response Relationship, Drug
- Female
- Guinea Pigs
- Humans
- Male