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Article

Herbal medicine yin zhi huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole.

Acta pharmacologica Sinica - 1 Oct 2007

Fan Lan, Wang Guo, Wang Lian-Sheng, Chen Yao, Zhang Wei, Huang Yuan-Fei, Huang Rui-Xue, Hu Dong-Li, Wang Dan, Zhou Hong-Hao

Abstract excerpt

AIM: To explore the potential interactions between yin zhi huang (YZH) and omeprazole, a substrate of CYP3A4 and CYP2C19. METHODS: Eighteen healthy volunteers, including 6 CYP2C19*1/*1, 6 CYP2C19*1/*2 or *3 and 6 CYP2C19*2/*2 were enrolled in a 2-phase, randomized, crossover clinical trial. In each phase, the volunteers received either placebo or 10 mL YZH oral liquid, 3 times daily for 14 d. Then all the...

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PMID: 17883958
DOI: 10.1111/j.1745-7254.2007.00617.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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