Article
Comparison of the kinetic disposition and metabolism of E3810, a new proton pump inhibitor, and omeprazole in relation to S-mephenytoin 4'-hydroxylation status.
Clinical pharmacology and therapeutics - 1 Aug 1995
Yasuda S, Horai Y, Tomono Y, Nakai H, Yamato C, Manabe K, Kobayashi K, Chiba K, Ishizaki T
Abstract excerpt
We studied the kinetic disposition and metabolism of E3810 [(+/-)-sodium 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl ]-1H- benzimidazole], a new proton pump inhibitor, and omeprazole in 15 Japanese male volunteers, six of whom were poor metabolizers and nine of whom were extensiv...
Topics
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Benzimidazoles
- Cross-Over Studies
- Humans
- Hydroxylation
- Japan
- Male
- Mephenytoin
- Omeprazole
- Phenotype
- Proton Pump Inhibitors
- Rabeprazole
- Reference Values
- Smoking