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Article

SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.

Nature neuroscience - 1 May 2011

Esteve Pilar, Sandonìs Africa, Cardozo Marcos, Malapeira Jordi, Ibañez Carmen, Crespo Inmaculada, Marcos Severine, Gonzalez-Garcia Sara, Toribio Maria Luisa, Arribas Joaquin, Shimono Akihiko, Guerrero Isabel, Bovolenta Paola

Abstract excerpt

It is well established that retinal neurogenesis in mouse embryos requires the activation of Notch signaling, but is independent of the Wnt signaling pathway. We found that genetic inactivation of Sfrp1 and Sfrp2, two postulated Wnt antagonists, perturbs retinal neurogenesis. In retinas from Sfrp1(-/-); Sfrp2(-/-) embryos, Notch signaling was transiently upregulated because Sfrps bind ADAM10 metalloprotease and...

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Source

Identifiers

PMID: 21478884
DOI: 10.1038/nn.2794

Genes

ADAM10
APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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