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Article

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.

Developmental cell - 1 Jan 2003

Itoh Motoyuki, Kim Cheol-Hee, Palardy Gregory, Oda Takaya, Jiang Yun-Jin, Maust Donovan, Yeo Sang-Yeob, Lorick Kevin, Wright Gavin J, Ariza-McNaughton Linda, Weissman Allan M, Lewis Julian, Chandrasekharappa Settara C, Chitnis Ajay B

Abstract excerpt

Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneural gene expression. Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons. Po...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12530964
DOI: 10.1016/s1534-5807(02)00409-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12530964-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.PMID 12530964Read ↗

Identification of the Mind Bomb1 Interaction Domain in Zebrafish DeltaD.Semantic proximity Read ↗

Mind bomb-2 is an E3 ligase for Notch ligand.Semantic proximity Read ↗

Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.Semantic proximity Read ↗

Interaction with Notch determines endocytosis of specific Delta ligands in zebrafish neural tissue.Semantic proximity Read ↗

The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.Semantic proximity Read ↗

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta.Semantic proximity Read ↗

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.Semantic proximity Read ↗

An obligatory role of mind bomb-1 in notch signaling of mammalian development.Semantic proximity Read ↗

The characterization of zebrafish antimorphic mib alleles reveals that Mib and Mind bomb-2 (Mib2) function redundantly.Semantic proximity Read ↗

Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.Semantic proximity Read ↗

Transcriptome analysis of the zebrafish mind bomb mutant.Semantic proximity Read ↗

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.Semantic proximity Read ↗

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