Article
The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase is essential for viability, and a single Leu-to-Pro mutation in a conserved sequence leads to thermosensitivity.
Journal of bacteriology - 1 Aug 1997
Bergès T, Guyonnet D, Karst F
Abstract excerpt
The mevalonate diphosphate decarboxylase is an enzyme which converts mevalonate diphosphate to isopentenyl diphosphate, the building block of isoprenoids. We used the Saccharomyces cerevisiae temperature-sensitive mutant defective for mevalonate diphosphate decarboxylase previously described (C....
Topics
- Alleles
- Carboxy-Lyases
- Cloning, Molecular
- Conserved Sequence
- Epitopes
- Gene Expression
- Genes, Fungal
- Leucine
- Mevalonic Acid
- Point Mutation
- Proline
- Saccharomyces cerevisiae
- Temperature