Article
Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway.
The Journal of biological chemistry - 18 Nov 2005
Fernández-Murray J Pedro, McMaster Christopher R
Abstract excerpt
In eukaryotes, neuropathy target esterase (Nte1p in yeast) deacylates phosphatidylcholine derived exclusively from the CDP-choline pathway to produce glycerophosphocholine (GroPCho) and release two fatty acids. The metabolic fate of GroPCho in eukaryotic cells is currently not known. Saccharomyces cerevisiae contains two open reading frames predicted to contain glycerophosphodiester phosphodiesterase domains,...
Topics
- Biochemistry
- Choline
- Cytidine Diphosphate Choline
- Fatty Acids
- Genotype
- Glucose
- Glycerylphosphorylcholine
- Inositol
- Models, Chemical
- Open Reading Frames
- Phosphates
- Phosphatidylcholines
- Phosphoric Diester Hydrolases
- Protein Structure, Tertiary
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Temperature
- Time Factors