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Article

A specific structural requirement for ergosterol in long-chain fatty acid synthesis mutants important for maintaining raft domains in yeast.

Molecular biology of the cell - 1 Dec 2002

Eisenkolb Marlis, Zenzmaier Christoph, Leitner Erich, Schneiter Roger

Abstract excerpt

Fungal sphingolipids contain ceramide with a very-long-chain fatty acid (C26). To investigate the physiological significance of the C26-substitution on this lipid, we performed a screen for mutants that are synthetically lethal with ELO3. Elo3p is a component of the ER-associated fatty acid elongase and is required for the final elongation cycle to produce C26 from C22/C24 fatty acids. elo3delta mutant cells thus...

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PMID: 12475962
DOI: 10.1091/mbc.e02-02-0116
PMCID: PMC138643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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