Characterization of a lysine-to-glutamic acid mutation in a conservative sequence of farnesyl diphosphate synthase from Saccharomyces cerevisiae.

doi:10.1016/0378-1119(93)90326-x

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Article

Characterization of a lysine-to-glutamic acid mutation in a conservative sequence of farnesyl diphosphate synthase from Saccharomyces cerevisiae.

Gene - 30 Mar 1993

Blanchard L, Karst F

Abstract excerpt

The mutant gene erg20-2 was isolated from a yeast strain defective in farnesyl diphosphate synthase (FPPS). This strain had the unusual property of excreting prenyl alcohols such as geraniol. The nucleotide (nt) sequence, compared with that of the wild-type gene, showed a single nt change, resulting in a Lys197-->Glu substitution in FPPS which is directly involved in terpenic alcohol formation. In addition,...

Topics

Acyclic Monoterpenes
Alkyl and Aryl Transferases
Alleles
Amino Acid Sequence
Animals
Base Sequence
Conserved Sequence
DNA, Fungal
Geranyltranstransferase
Glutamates
Glutamic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lysine

Molecular Sequence Data

Mutation

Restriction Mapping

Saccharomyces cerevisiae

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 8096487
DOI: 10.1016/0378-1119(93)90326-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8096487-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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