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Article

Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix.

9 Jan 1996

Abstract excerpt

We have chosen tumors of the uterine cervix as a model system to identify chromosomal aberrations that occur during carcinogenesis. A phenotype/genotype correlation was established in defined regions of archived, formalin-fixed, and hematoxylin/eosin-stained tissue sections that were dissected from normal cervical epithelium (n = 3), from mild (n = 4), moderate (n = 6), and severe dysplasias/carcinomas in situ...

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Identifiers

PMID: 8552665
DOI: 10.1073/pnas.93.1.479

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Related research

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Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix.PMID 8552665Read ↗

Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3qSemantic proximity Read ↗

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Progressive genetic aberrations detected by comparative genomic hybridization in squamous cell cervical cancerSemantic proximity Read ↗

Chromosomal Signatures of a Subset of High-Grade Premalignant Cervical Lesions Closely Resemble Invasive CarcinomasSemantic proximity Read ↗

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Frequent gain of copy number on the long arm of chromosome 3 in human cervical adenocarcinomaSemantic proximity Read ↗

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