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Comparative genomic hybridization detects genetic alterations during early stages of cervical cancer progression

8 Nov 2001

Abstract excerpt

Invasive cervical carcinoma is thought to arise from cervical intraepithelial neoplasm (CIN). Genetic changes that occur during progression of CIN to cervical carcinoma are poorly understood, although they appear to be directly involved in this process. We used comparative genomic hybridization (CGH) with precise microdissection and degenerate oligonucleotide primed-polymerase chain reaction (DOP-PCR) to detect...

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PMID: 11746992
DOI: 10.1002/gcc.1215

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