Article
Aberrant splicing but not mutations of TSG101 in human breast cancer.
Cancer research - 1 Aug 1997
Lee M P, Feinberg A P
Abstract excerpt
The 11p15 gene TSG101 was recently reported to undergo frequent large intragenic deletions in human breast cancer. Here we show that that is generally not the case, but the gene shows aberrant splicing, based on the following observations: identical products were observed in matching normal and fetal tissues; deleted cDNA sequence revealed canonical splicing donor and acceptor site sequences; and genomic Southern...
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