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Article

Tsg101 Is Essential for Cell Growth, Proliferation, and Cell Survival of Embryonic and Adult Tissues

13 Dec 2002

Abstract excerpt

Tumor susceptibility gene 101 (Tsg101) was identified in a random mutagenesis screen for potential tumor suppressors in NIH 3T3 cells. Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic transformation and tumorigenesis is still elusive. Using gene targeting, we generated genetically engineered mice...

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PMID: 12482969
DOI: 10.1128/mcb.23.1.150-162.2003

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Tsg101 Is Essential for Cell Growth, Proliferation, and Cell Survival of Embryonic and Adult TissuesPMID 12482969Read ↗

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Consecutive inactivation of both alleles of the gb110 gene has no effect on the proliferation and differentiation of mouse embryonic stem cells.Semantic proximity Read ↗

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