Article
Clinical implications of aberrant TSG101 transcripts in acute myeloblastic leukemia.
Leukemia & lymphoma - 1 Feb 2000
Lin S F, Lin P M, Liu T C, Chang J G, Sue Y C, Chen T P
Abstract excerpt
Tsg101 is a mouse tumor suppressor gene whose homozygous deletion produces transformation of NIH3T3 cells and leads to metastases in nude mice. The human homologue of the gene, TSG101, is localized in chromosome 11p15.1-p15.2. Reduced TSG101 expression may cause the defect of the cell cycle checkpoint that leads to genetic instability and consequently to the progression of neoplasia. Aberrant TSG101 transcript...
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