Article
TSG101 is not mutated in lung cancer but a shortened transcript is frequently expressed in small cell lung cancer.
Oncogene - 3 Sept 1998
Oh Y, Proctor M L, Fan Y H, Su L K, Hong W K, Fong K M, Sekido Y S, Gazdar A F, Minna J D, Mao L
Abstract excerpt
TSG101 is a candidate tumor suppressor gene whose deletion in NIH3T3 cells leads to spontaneous lung metastases in nude mice. Aberrant transcripts of TSG101 have been identified in 47% of primary breast carcinomas, without evidence of intragenic deletions at the TSG101 locus on 11p15. To investig...
Topics
- Blotting, Northern
- Blotting, Southern
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- DNA Mutational Analysis
- DNA, Complementary
- DNA, Neoplasm
- DNA-Binding Proteins
- Endosomal Sorting Complexes Required for Transport
- Gene Expression
- Humans
- Lung Neoplasms
- Mutation
- Polymerase Chain Reaction