Article
TSG101 is not mutated in lung cancer but a shortened transcript is frequently expressed in small cell lung cancer.
Oncogene - 3 Sept 1998
Oh Y, Proctor M L, Fan Y H, Su L K, Hong W K, Fong K M, Sekido Y S, Gazdar A F, Minna J D, Mao L
Abstract excerpt
TSG101 is a candidate tumor suppressor gene whose deletion in NIH3T3 cells leads to spontaneous lung metastases in nude mice. Aberrant transcripts of TSG101 have been identified in 47% of primary breast carcinomas, without evidence of intragenic deletions at the TSG101 locus on 11p15. To investigate the possible role of TSG101 in lung cancer, which often shows 11p allele loss, we performed transcript analysis and...
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