Article
Identification of cellular TSG101 protein in multiple human breast cancer cell lines.
Cancer research - 1 Oct 1997
Zhong Q, Chen C F, Chen Y, Chen P L, Lee W H
Abstract excerpt
tsg101 was identified as a tumor susceptibility gene by homozygous functional inactivation of allelic loci in mouse 3T3 fibroblasts. The human homologue was mapped at chromosome 11p15.1-2 and found to have intragenic deletion in 7 of 15 breast cancer specimens. To further confirm the relevance of defects in this gene to breast cancer, antibodies specific for the putative gene product were prepared and used to...
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