Article
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Nature genetics - 1 Aug 1997
Fleming M D, Trenor C C, Su M A, Foernzler D, Beier D R, Dietrich W F, Andrews N C
Abstract excerpt
Although disorders of iron metabolism are prevalent, iron transport remains poorly understood. To address this problem, we undertook a positional cloning strategy to identify the causative mutation in mice with microcytic anaemia (mk). Homozygous mk/mk mice have microcytic, hypochromic anaemia due to severe defects in intestinal iron absorption and erythroid iron utilization. We report the identification of a...
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