Article
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Nature genetics - 1 Aug 1997
Fleming M D, Trenor C C, Su M A, Foernzler D, Beier D R, Dietrich W F, Andrews N C
Abstract excerpt
Although disorders of iron metabolism are prevalent, iron transport remains poorly understood. To address this problem, we undertook a positional cloning strategy to identify the causative mutation in mice with microcytic anaemia (mk). Homozygous mk/mk mice have microcytic, hypochromic anaemia du...
Topics
- Amino Acid Sequence
- Anemia
- Animals
- Biological Transport
- Carrier Proteins
- Cation Transport Proteins
- Disease Models, Animal
- Female
- Haplotypes
- Heterozygote
- Humans
- Iron
- Iron-Binding Proteins
- Male
- Membrane Proteins
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL