Article
Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.
Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 1998
Fleming M D, Romano M A, Su M A, Garrick L M, Garrick M D, Andrews N C
Abstract excerpt
The Belgrade (b) rat has an autosomal recessively inherited, microcytic, hypochromic anemia associated with abnormal reticulocyte iron uptake and gastrointestinal iron absorption. The b reticulocyte defect appears to be failure of iron transport out of endosomes within the transferrin cycle. Aspe...
Topics
- Alleles
- Amino Acid Sequence
- Anemia, Hypochromic
- Animals
- Arginine
- Biological Transport
- Carrier Proteins
- Cation Transport Proteins
- Chromosome Mapping
- Codon
- Endosomes
- Genetic Linkage
- Genotype
- Glycine
- Iron
- Iron-Binding Proteins
- Membrane Proteins
- Mice