Article
The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms.
Blood cells, molecules & diseases - 1 Jun 1998
Lee P L, Gelbart T, West C, Halloran C, Beutler E
Abstract excerpt
Nramp2 is a gene encoding a transmembrane protein that is important in metal transport, in particular iron. Mutations in nramp2 have been shown to be associated with microcytic anemia in mk/mk mice and defective iron transport in Belgrade rats. Nramp2 contains a classical iron responsive element in the 3' untranslated region that confers iron dependent mRNA stabilization. In this report, we describe a splice...
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