Article
The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms.
Blood cells, molecules & diseases - 1 Jun 1998
Lee P L, Gelbart T, West C, Halloran C, Beutler E
Abstract excerpt
Nramp2 is a gene encoding a transmembrane protein that is important in metal transport, in particular iron. Mutations in nramp2 have been shown to be associated with microcytic anemia in mk/mk mice and defective iron transport in Belgrade rats. Nramp2 contains a classical iron responsive element...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Base Sequence
- Carrier Proteins
- Cation Transport Proteins
- DNA Mutational Analysis
- DNA, Complementary
- Exons
- Gene Expression Regulation
- Genes
- Genetic Heterogeneity
- Genotype
- Hemochromatosis
- Humans
- Introns
- Iron
- Iron-Binding Proteins