Article
The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border.
Blood - 1 Dec 2000
Canonne-Hergaux F, Fleming M D, Levy J E, Gauthier S, Ralph T, Picard V, Andrews N C, Gros P
Abstract excerpt
Microcytic anemia (mk) mice and Belgrade (b) rats are severely iron deficient because of impaired intestinal iron absorption and defective iron metabolism in peripheral tissues. Both animals carry a glycine to arginine substitution at position 185 in the iron transporter known as Nramp2/DMT1 (divalent metal transporter 1). DMT1 messenger RNA (mRNA) and protein expression has been examined in the gastrointestinal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.