Article
Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2.
Nature - 22 Apr 1993
Peters L L, Andrews N C, Eicher E M, Davidson M B, Orkin S H, Lux S E
Abstract excerpt
The nuclear DNA-binding protein NF-E2 is thought to mediate the powerful erythroid enhancer activity of the alpha- and beta-globin locus control regions and participates in the control of genes encoding two enzymes of haem biosynthesis (porphobilinogen deaminase and ferrochelatase). The major com...
Topics
- Amino Acid Sequence
- Anemia
- Animals
- Base Sequence
- Chromosome Mapping
- DNA
- DNA-Binding Proteins
- Duodenum
- Enhancer Elements, Genetic
- Erythroid-Specific DNA-Binding Factors
- Globins
- Iron
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Molecular Sequence Data
- Mutation