Article
Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2.
Nature - 22 Apr 1993
Peters L L, Andrews N C, Eicher E M, Davidson M B, Orkin S H, Lux S E
Abstract excerpt
The nuclear DNA-binding protein NF-E2 is thought to mediate the powerful erythroid enhancer activity of the alpha- and beta-globin locus control regions and participates in the control of genes encoding two enzymes of haem biosynthesis (porphobilinogen deaminase and ferrochelatase). The major component of NF-E2 is a 45K polypeptide (designated p45 NF-E2) that belongs to the basic region-leucine zipper family of...
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