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Article

A role of PIEZO1 in iron metabolism in mice and humans.

Cell - 18 Feb 2021

Ma Shang, Dubin Adrienne E, Zhang Yunxiao, Mousavi Seyed Ali Reza, Wang Yu, Coombs Adam M, Loud Meaghan, Andolfo Immacolata, Patapoutian Ardem

Abstract excerpt

Iron overload causes progressive organ damage and is associated with arthritis, liver damage, and heart failure. Elevated iron levels are present in 1%-5% of individuals; however, iron overload is undermonitored and underdiagnosed. Genetic factors affecting iron homeostasis are emerging. Individuals with hereditary xerocytosis, a rare disorder with gain-of-function (GOF) mutations in mechanosensitive PIEZO1 ion...

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Source

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Identifiers

PMID: 33571427
DOI: 10.1016/j.cell.2021.01.024
PMCID: PMC7927959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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