Article
Congenital heart block: HLA differences between affected children and healthy siblings in four Finnish families.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Jun 1997
Sirén M K, Julkunen H, Kaaja R, Koskimies S
Abstract excerpt
Congenital heart block without intracardiac anatomic malformations is a potentially lethal disease affecting children and newborns. The mother often has an autoimmune disorder with autoantibodies against SS-A/Ro and/or SS-B/La antigens. However, only a minority of the children of these mothers develop complete heart block. It is believed that the maternal antibodies are pathogenic, but other immunological...
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