Article
Association of Natural Killer Cell Ligand Polymorphism HLA-C Asn80Lys With the Development of Anti-SSA/Ro-Associated Congenital Heart Block.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Nov 2017
Ainsworth Hannah C, Marion Miranda C, Bertero Tiziana, Brucato Antonio, Cimaz Rolando, Costedoat-Chalumeau Nathalie, Fredi Micaela, Gaffney Patrick, Kelly Jennifer, Levesque Kateri, Maltret Alice, Morel Nathalie, Ramoni Veronique, Ruffatti Amelia, Langefeld Carl D, Buyon Jill P, Clancy Robert M
Abstract excerpt
OBJECTIVE: Fetal exposure to maternal anti-SSA/Ro antibodies is necessary but not sufficient for the development of autoimmune congenital heart block (CHB), suggesting that other factors, such as fetal genetic predisposition, are important. Given the previously described association between major histocompatibility complex alleles and CHB risk, we undertook the present study to test the hypothesis that a variant...
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