Article
Neonatal lupus erythematosus: studies on HLA class II genes and autoantibody profiles in Japanese mothers.
Autoimmunity - 1 Jan 1997
Miyagawa S, Shinohara K, Kidoguchi K, Fujita T, Fukumoto T, Hashimoto K, Yoshioka A, Shirai T
Abstract excerpt
Neonatal lupus erythematosus (NLE) is a rare disorder of neonates characterized by two major clinical manifestations: congenital heart block and cutaneous lupus lesions. The disease is associated with placentally transferred maternal anti-Ro/SSA and/or La/SSB antibodies. To clarify possible class...
Topics
- Animals
- Antibodies, Antinuclear
- Autoantibodies
- DNA
- Enzyme-Linked Immunosorbent Assay
- Female
- Gene Frequency
- Genes, MHC Class II
- Genotype
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Heart Block
- Humans
- Infant, Newborn
- Japan
- Lupus Erythematosus, Cutaneous
- Lupus Erythematosus, Systemic