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Article

Congenital heart block: evidence for a pathogenic role of maternal autoantibodies

1 Jan 2012

Abstract excerpt

During pregnancy in autoimmune conditions, maternal autoantibodies are transported across the placenta and may affect the developing fetus. Congenital heart block (CHB) is known to associate with the presence of anti-Ro/SSA and anti-La/SSB antibodies in the mother and is characterized by a block in signal conduction at the atrioventricular (AV) node. The mortality rate of affected infants is 15% to 30%, and most...

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PMID: 22546326
DOI: 10.1186/ar3787

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