Article
DNA typing of maternal HLA in congenital complete heart block: comparison with systemic lupus erythematosus and primary Sjögren's syndrome.
Arthritis and rheumatism - 1 Aug 1999
Colombo G, Brucato A, Coluccio E, Compasso S, Luzzana C, Franceschini F, Quinzanini M, Scorza R
Abstract excerpt
OBJECTIVE: To investigate which maternal HLA allele or haplotype is primarily associated with isolated congenital complete heart block (CCHB) in offspring. METHODS: HLA class II typings were assessed by line probe assay and polymerase chain reaction-sequence-specific oligonucleotide probe methods, and HLA class I by the microlymphocytotoxicity test, in 13 Italian anti-Ro-positive mothers of children with CCHB and...
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