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Article

Role of HLA in congenital heart block: susceptibility alleles in mothers.

Lupus - 1 Jan 1999

Sirén M K, Julkunen H, Kaaja R, Kurki P, Koskimies S

Abstract excerpt

In congenital heart block (CHB), abnormal maternal immunisation leads to autoantibody production against SS-A/Ro and SS-B/La antigens. These maternal antibodies are transferred across the placenta to the unborn child and are believed to transmit irreversible immunological injury in developing foetal heart tissue, thus causing 3rd-degree atrioventricular block. The mothers may suffer from systemic lupus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10025599
DOI: 10.1191/096120399678847399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of HLA in congenital heart block: susceptibility alleles in mothers.PMID 10025599Read ↗

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