Article
HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population.
The Journal of rheumatology - 1 Nov 2004
Säilä Hanna, Pitkäniemi Janne, Tuomilehto Jaakko, Savolainen Anneli, Alakulppi Noora, Tuomilehto-Wolf Eva, Leirisalo-Repo Marjatta, Aho Kimmo
Abstract excerpt
OBJECTIVE: To determine the effects of class I (A, B, and C) and II (DRB1 and DQB1) HLA loci alleles and DRB1-DQB1 haplotypes on genetic susceptibility to juvenile idiopathic arthritis (JIA) in families with 2 or more affected siblings. METHODS: A total of 83 affected siblings belonging to 38 families and corresponding to 50 affected sibpairs, their parents, and 45 healthy sibs were typed for HLA in A, C, B,...
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