Article
Idiopathic dilated cardiomyopathy: lack of association between circulating organ-specific cardiac antibodies and HLA-DR antigens.
Tissue antigens - 1 May 1992
Caforio A L, Martinetti M, Schwarz G, Bonifacio E, Gavazzi A, Graziano G, Lorini R, Cuccia M, McKenna W J, Bottazzo G F
Abstract excerpt
Organ-specific cardiac antibodies are serological markers of autoimmunity in dilated cardiomyopathy (DCM). HLA-DR4 and possibly DR5 are immunogenetic markers of susceptibility in DCM, but it is not known whether they are associated with autoantibody production. We studied the frequency of HLA-DR antigens and the presence of organ-specific cardiac antibodies in 80 DCM Caucasian patients from Northern Italy. HLA-DR...
Topics
- Adult
- Alleles
- Antibody Specificity
- Autoantibodies
- Autoimmune Diseases
- Cardiomyopathy, Dilated
- Disease Susceptibility
- Female
- Genetic Markers
- Genetic Predisposition to Disease