The WT1 protein is a negative regulator of the normal bcl-2 allele in t(14;18) lymphomas.

doi:10.1074/jbc.272.31.19609

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Article

The WT1 protein is a negative regulator of the normal bcl-2 allele in t(14;18) lymphomas.

The Journal of biological chemistry - 1 Aug 1997

Heckman C, Mochon E, Arcinas M, Boxer L M

Abstract excerpt

The translocated and normal bcl-2 alleles in the DHL-4 cell line with the t(14;18) translocation were separated by pulsed field electrophoresis. An in vivo footprint over a potential WT1 binding site in the bcl-2 5'-flanking sequence was identified on the normal silent allele. Electrophoretic mob...

Topics

Alleles
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
DNA-Binding Proteins
Enhancer Elements, Genetic
Genes, Immunoglobulin
Genes, bcl-2
Humans
Lymphoma
Promoter Regions, Genetic
Transcription Factors
Translocation, Genetic
Tumor Cells, Cultured
WT1 Proteins

Source

Open in PubMed

Identifiers

PMID: 9235968
DOI: 10.1074/jbc.272.31.19609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9235968-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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