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Article

Transcriptional regulation of the BCL-6 gene: mechanistic dissection using mutant cell lines.

Molecular medicine (Cambridge, Mass.) - 1 Oct 2002

Zhou Gang, Ono Santa Jeremy

Abstract excerpt

BACKGROUND: Mice lacking the BCL-6 gene product exhibit overexpression of T helper cell type 2 cytokines, and multi-organ inflammatory responses characterized by eosinophilia and infiltration by IgE+ B lymphocytes. Elevated IgE levels appear to result from loss of BCL-6's role in repression of the Stat6-dependent processes of I-epsilon transcription and IgE class-switching. Understanding the regulation of the...

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PMID: 12477975
PMCID: PMC2039941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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