Article
CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas.
The Journal of biological chemistry - 13 Sept 1996
Ji L, Mochon E, Arcinas M, Boxer L M
Abstract excerpt
The translocated and normal bcl-2 alleles in the DHL-4 cell line with the t(14;18) translocation were separated by pulsed field electrophoresis. An in vivo footprint over a cAMP response element (CRE) in the bcl-2 5'-flanking sequence was identified on the translocated allele. Electrophoretic mobility shift assays with the bcl-2 CRE demonstrated complexes with mobilities identical to those with a consensus CRE....
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