Article
CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas.
The Journal of biological chemistry - 13 Sept 1996
Ji L, Mochon E, Arcinas M, Boxer L M
Abstract excerpt
The translocated and normal bcl-2 alleles in the DHL-4 cell line with the t(14;18) translocation were separated by pulsed field electrophoresis. An in vivo footprint over a cAMP response element (CRE) in the bcl-2 5'-flanking sequence was identified on the translocated allele. Electrophoretic mob...
Topics
- Alleles
- Animals
- Base Sequence
- Blotting, Western
- Cell Line
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 18
- Cyclic AMP Response Element-Binding Protein
- DNA Footprinting
- Electrophoresis, Gel, Pulsed-Field
- Electrophoresis, Polyacrylamide Gel
- Gene Expression Regulation, Neoplastic
- Humans
- Immunoglobulin Heavy Chains
- Lymphoma
- Molecular Sequence Data
- Proto-Oncogene Proteins c-bcl-2
- Tetradecanoylphorbol Acetate