Somatic point mutations in the translocated bcl-2 genes of non-Hodgkin's lymphomas and lymphocytic leukemias: implications for mechanisms of tumor progression.

Abstract excerpt

The t[14;18] chromosomal translocation is the most common cytogenetic abnormality found in hematolymphoid malignancies. The t[14;18] fuses the bcl-2 gene at 18q21 with the immunoglobulin heavy-chain locus at 14q32, resulting in deregulated expression of bcl-2 and production of high levels of its...

Topics

• Alleles
• Amino Acid Sequence
• Animals
• Cell Transformation, Neoplastic
• Chromosomes, Human, Pair 14
• Chromosomes, Human, Pair 18
• Humans
• Leukemia, Lymphoid
• Lymphoma, Non-Hodgkin
• Mice
• Molecular Sequence Data
• Open Reading Frames
• Point Mutation
• Proto-Oncogene Proteins
• Proto-Oncogene Proteins c-bcl-2
• Sequence Alignment
• Translocation, Genetic